Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.2362 | 0.6235 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0041 | 0.3111 | 0.8213 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.2362 | 0.6235 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3788 | 1 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0809 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3788 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0021 | 0.0306 | 0.0306 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2362 | 0.6235 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.2362 | 0.6235 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 1 | 1 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.0306 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3788 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3788 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3788 | 1 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0041 | 0.3111 | 0.8213 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.0306 | 0.0809 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0041 | 0.3111 | 0.8213 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3788 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.0041 | 0.3111 | 0.8213 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0021 | 0.0306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3111 | 0.8213 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.2362 | 0.6235 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0306 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3788 | 1 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0021 | 0.0306 | 0.0809 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Leishmania major | modification methylase-like protein | 0.0021 | 0.0306 | 1 |
Onchocerca volvulus | 0.0041 | 0.3111 | 1 | |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0021 | 0.0306 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2362 | 0.6235 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2362 | 0.6235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3788 | 1 |
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0021 | 0.0306 | 0.0306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.