Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0324 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0324 | 0.0628 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5148 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0324 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.2121 | 0.3725 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0324 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2121 | 0.4119 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0324 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0088 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0324 | 0.0628 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0324 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.004 | 0.2894 | 0.5621 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2121 | 0.4119 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.2121 | 0.4119 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0324 | 0.0324 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5148 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0324 | 1 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.004 | 0.2894 | 0.5621 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0324 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0324 | 0.5 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.004 | 0.2894 | 0.5328 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2894 | 0.5328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5148 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.5148 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5148 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5148 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0324 | 0.0628 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0324 | 0.5 |
Echinococcus multilocularis | disco interacting protein 2 | 0.004 | 0.2894 | 0.5621 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0324 | 1 |
Onchocerca volvulus | 0.004 | 0.2894 | 1 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.2121 | 0.3725 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5148 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0324 | 0.0628 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.2121 | 0.4119 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.5148 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0324 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0324 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.2121 | 0.4119 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0324 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.