Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0104 | 0.2632 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0938 | 0.2217 |
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.0104 | 0.2632 | 1 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.0104 | 0.2632 | 1 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.0104 | 0.2632 | 1 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0294 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.02 | 0.0474 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0294 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.02 | 1 |
Brugia malayi | S-adenosylmethionine decarboxylase proenzyme | 0.0104 | 0.2632 | 0.6222 |
Treponema pallidum | cell division protein FtsZ | 0.0294 | 1 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.0141 | 0.4073 | 0.9629 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0938 | 0.3564 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0104 | 0.2632 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.0145 | 0.423 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0051 | 0.0567 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0104 | 0.2632 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0294 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0104 | 0.2632 | 1 |
Leishmania major | S-adenosylmethionine decarboxylase | 0.0104 | 0.2632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.02 | 0.0761 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0938 | 0.2217 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0938 | 0.3564 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0051 | 0.0567 | 1 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0104 | 0.2632 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.