Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0908 | 0.0862 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0908 | 0.0725 |
Leishmania major | clathrin heavy chain, putative | 0.0143 | 0.532 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.8441 | 0.8285 |
Schistosoma mansoni | clathrin heavy chain | 0.0066 | 0.1429 | 0.1494 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0125 | 0.4421 | 0.5 |
Echinococcus granulosus | clathrin heavy chain | 0.0236 | 1 | 1 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.0143 | 0.532 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1158 | 0.098 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0158 | 0.6109 | 1 |
Giardia lamblia | Clathrin heavy chain | 0.0066 | 0.1429 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1158 | 0.098 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0158 | 0.6109 | 0.5 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0143 | 0.532 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1158 | 0.098 |
Trypanosoma brucei | clathrin heavy chain | 0.0143 | 0.532 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8441 | 0.8285 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8441 | 1 |
Schistosoma mansoni | clathrin heavy chain | 0.0066 | 0.1429 | 0.1494 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0908 | 0.0862 |
Loa Loa (eye worm) | clathrin | 0.0236 | 1 | 1 |
Toxoplasma gondii | clathrin heavy chain, putative | 0.0066 | 0.1429 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0908 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1158 | 0.098 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8441 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0908 | 0.0725 |
Echinococcus multilocularis | clathrin heavy chain | 0.0236 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.