Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | clathrin heavy chain, putative | 0.0304 | 0.5438 | 1 |
Echinococcus multilocularis | clathrin heavy chain | 0.0501 | 1 | 0.5 |
Loa Loa (eye worm) | clathrin | 0.0501 | 1 | 0.5 |
Toxoplasma gondii | clathrin heavy chain, putative | 0.0139 | 0.1646 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0337 | 0.6208 | 1 |
Trypanosoma brucei | clathrin heavy chain | 0.0304 | 0.5438 | 1 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0266 | 0.4562 | 0.5 |
Leishmania major | clathrin heavy chain, putative | 0.0304 | 0.5438 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0269 | 0.463 | 0.7459 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0304 | 0.5438 | 1 |
Giardia lamblia | Clathrin heavy chain | 0.0139 | 0.1646 | 0.5 |
Echinococcus granulosus | clathrin heavy chain | 0.0501 | 1 | 0.5 |
Schistosoma mansoni | clathrin heavy chain | 0.0139 | 0.1646 | 0.5 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0337 | 0.6208 | 0.5 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0079 | 0.0253 | 1 |
Schistosoma mansoni | clathrin heavy chain | 0.0139 | 0.1646 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.