Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0078 | 0.0253 | 1 |
Echinococcus multilocularis | clathrin heavy chain | 0.0494 | 1 | 0.5 |
Leishmania major | clathrin heavy chain, putative | 0.0299 | 0.5438 | 0.5 |
Giardia lamblia | Clathrin heavy chain | 0.0137 | 0.1646 | 0.5 |
Toxoplasma gondii | clathrin heavy chain, putative | 0.0137 | 0.1646 | 0.5 |
Echinococcus granulosus | clathrin heavy chain | 0.0494 | 1 | 0.5 |
Schistosoma mansoni | clathrin heavy chain | 0.0137 | 0.1646 | 0.5 |
Trypanosoma brucei | clathrin heavy chain | 0.0299 | 0.5438 | 1 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0299 | 0.5438 | 1 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0332 | 0.6208 | 1 |
Loa Loa (eye worm) | clathrin | 0.0494 | 1 | 0.5 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0332 | 0.6208 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0265 | 0.463 | 0.7459 |
Schistosoma mansoni | clathrin heavy chain | 0.0137 | 0.1646 | 0.5 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0262 | 0.4562 | 0.5 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.0299 | 0.5438 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.