Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0054 | 0.4122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0054 | 0.4122 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0054 | 0.4122 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0054 | 0.4122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4122 | 0.4122 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0054 | 0.4122 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0054 | 0.4122 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4122 | 0.4122 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.004 | 0.199 | 0.199 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2132 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4122 | 0.4122 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0054 | 0.4122 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.