pI: 4.5025 |
Length (AA): 85 |
MW (Da): 9779 |
Paralog Number:
15
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 84 | 3dwb (A) | 114 | 196 | 33.00 | 0.000000000014 | 0.23 | 1.27847 | 0.44 |
2 | 74 | 3t2n (L) | 72 | 136 | 34.00 | 0.56 | 0.22 | 0.861824 | 2.32 |
9 | 81 | 4iuw (A) | 6 | 79 | 14.00 | 0 | 0.04 | 0.941224 | 0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127344)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_43745 | Peptidase family M13 containing protein |
Brugia malayi | Bm1_50770 | Hypothetical zinc metalloproteinase T16A9.4 |
Caenorhabditis elegans | CELE_F18A12.8 | Protein NEP-11, isoform A |
Caenorhabditis elegans | CELE_T05A8.4 | Protein NEP-2 |
Caenorhabditis elegans | CELE_T16A9.4 | Protein NEP-21, isoform A |
Drosophila melanogaster | Dmel_CG4058 | Neprilysin 4 |
Drosophila melanogaster | Dmel_CG5905 | Neprilysin 1 |
Drosophila melanogaster | Dmel_CG9565 | Neprilysin 3 |
Echinococcus granulosus | EgrG_001177500 | endothelin converting enzyme 1 |
Echinococcus multilocularis | EmuJ_001177500 | endothelin converting enzyme 1 |
Homo sapiens | ENSG00000142606 | membrane metallo-endopeptidase-like 1 |
Homo sapiens | ENSG00000117298 | endothelin converting enzyme 1 |
Homo sapiens | ENSG00000145194 | endothelin converting enzyme 2 |
Homo sapiens | ENSG00000196549 | membrane metallo-endopeptidase |
Loa Loa (eye worm) | LOAG_14244 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10000 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01595 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15321 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12742 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15702 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15151 | peptidase family M13 containing protein |
Loa Loa (eye worm) | LOAG_14395 | peptidase family M13 containing protein |
Loa Loa (eye worm) | LOAG_14655 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15429 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12845 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14818 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15355 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14969 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14910 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00293 | hypothetical protein |
Mycobacterium leprae | ML2613c | probable zinc metalloprotease |
Mus musculus | 17380 | membrane metallo endopeptidase |
Mus musculus | ENSMUSG00000058183 | membrane metallo-endopeptidase-like 1 |
Mus musculus | ENSMUSG00000057530 | endothelin converting enzyme 1 |
Mycobacterium tuberculosis | Rv0198c | Probable zinc metalloprotease Zmp1 |
Mycobacterium ulcerans | MUL_1088 | zinc metalloprotease |
Neospora caninum | NCLIV_002180 | hypothetical protein |
Onchocerca volvulus | OVOC12619 |
|
Schistosoma japonicum | Sjp_0217440 | ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative |
Schistosoma japonicum | Sjp_0115870 | IPR000718,Peptidase M13, neprilysin,domain-containing |
Schistosoma mansoni | Smp_159370 | family M13 unassigned peptidase (M13 family) |
Schmidtea mediterranea | mk4.004213.03 | AT14086p |
Schmidtea mediterranea | mk4.005225.04 | AT14086p |
Schmidtea mediterranea | mk4.065770.00 | AT14086p |
Schmidtea mediterranea | mk4.000478.03 | |
Schmidtea mediterranea | mk4.005782.00 | AT14086p |
Schmidtea mediterranea | mk4.005225.01 | |
Schmidtea mediterranea | mk4.001108.04 | AT14086p |
Schmidtea mediterranea | mk4.005225.02 | AT14086p |
Schmidtea mediterranea | mk4.013196.02 | |
Schmidtea mediterranea | mk4.040373.01 | |
Schmidtea mediterranea | mk4.013196.04 | Kell blood group glycoprotein |
Schmidtea mediterranea | mk4.013196.00 | |
Toxoplasma gondii | TGME49_295640 | peptidase family M13 protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_295640 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Oryctolagus cuniculus | Neprilysin | Compounds | References |
Homo sapiens | membrane metallo-endopeptidase-like 1 | Compounds | References |
Bos taurus | Endothelin-converting enzyme 1 | Compounds | References |
Homo sapiens | endothelin converting enzyme 1 | Compounds | References |
Mus musculus | membrane metallo endopeptidase | Compounds | References |
Sus scrofa | Neprilysin | Compounds | References |
Rattus norvegicus | Neprilysin | Compounds | References |
Homo sapiens | endothelin converting enzyme 2 | Compounds | References |
Rattus norvegicus | Endothelin-converting enzyme 1 | Compounds | References |
Homo sapiens | membrane metallo-endopeptidase | Compounds | References |