Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | clathrin heavy chain, putative | 0.0147 | 0.2174 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0283 | 0.497 | 0.7459 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0355 | 0.6448 | 0.5 |
Loa Loa (eye worm) | clathrin | 0.0528 | 1 | 1 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.032 | 0.5726 | 1 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.028 | 0.4906 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0391 | 0.0391 |
Trypanosoma brucei | clathrin heavy chain | 0.032 | 0.5726 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0391 | 0.0391 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0355 | 0.6448 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0391 | 0.0391 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.032 | 0.5726 | 1 |
Schistosoma mansoni | clathrin heavy chain | 0.0147 | 0.2174 | 1 |
Schistosoma mansoni | clathrin heavy chain | 0.0147 | 0.2174 | 1 |
Echinococcus granulosus | clathrin heavy chain | 0.0528 | 1 | 0.5 |
Echinococcus multilocularis | clathrin heavy chain | 0.0528 | 1 | 0.5 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0083 | 0.0869 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0391 | 0.0391 |
Giardia lamblia | Clathrin heavy chain | 0.0147 | 0.2174 | 0.5 |
Leishmania major | clathrin heavy chain, putative | 0.032 | 0.5726 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.006 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.