Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | flavodoxin family protein | 0.0175 | 0.0974 | 0.0974 |
Treponema pallidum | flavodoxin | 0.0175 | 0.0974 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0456 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.023 | 0.2747 | 0.0151 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0456 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0175 | 0.0974 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0456 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0456 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0456 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0456 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0404 | 0.8338 | 0.8159 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0456 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0282 | 0.4408 | 0.4408 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0404 | 0.8338 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0456 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0175 | 0.0974 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0456 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0456 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0175 | 0.0974 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0404 | 0.8338 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0226 | 0.2635 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0456 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0456 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0404 | 0.8338 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0456 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0456 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0282 | 0.4408 | 0.4408 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0456 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0456 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0456 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0282 | 0.4408 | 0.2407 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0175 | 0.0974 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0456 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0456 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0175 | 0.0974 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0226 | 0.2635 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0456 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0404 | 0.8338 | 0.8159 |
Brugia malayi | flavodoxin family protein | 0.0175 | 0.0974 | 0.0974 |
Chlamydia trachomatis | sulfite reductase | 0.0282 | 0.4408 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0456 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.