Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 0.555 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0106 | 0.555 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.2074 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0106 | 0.555 | 0.555 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0106 | 0.555 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0106 | 0.555 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.2074 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 0.555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2074 | 0.3737 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0046 | 0.1508 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0106 | 0.555 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.2074 | 0.2074 |
Schistosoma mansoni | glycogen phosphorylase | 0.0046 | 0.1508 | 0.1508 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.2074 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0046 | 0.1508 | 0.2717 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0106 | 0.555 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.099 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.2074 | 0.2074 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0106 | 0.555 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0046 | 0.1508 | 0.2717 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.099 | 0.4775 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0046 | 0.1508 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0106 | 0.555 | 0.555 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0046 | 0.1508 | 0.2717 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.099 | 0.4775 |
Schistosoma mansoni | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Echinococcus granulosus | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.2074 | 0.2074 |
Echinococcus granulosus | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Schistosoma mansoni | glycogen phosphorylase | 0.0106 | 0.555 | 0.555 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0106 | 0.555 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.2074 | 0.3737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2818 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.