Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0044 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.098 | 0.1626 | 1 |
Treponema pallidum | licC protein (licC) | 0.098 | 0.1626 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0.0025 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.58 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0225 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.58 | 1 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0044 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.58 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0044 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.0025 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.0225 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | ORL1-like opioid receptor | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.0025 | 0.1123 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0044 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0044 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0044 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0044 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0.0025 | 1 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0025 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0044 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.0025 | 1 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Onchocerca volvulus | 0.0044 | 0 | 0.5 | |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0044 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0044 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.0025 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.0025 | 0.5 |
Onchocerca volvulus | 0.0044 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140000 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
IC50 (binding) | = 140000 nM | The compound was tested for its inhibitory activity against human renal renin at pH 7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.