Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jun-related protein | 0.0073 | 0.1898 | 0.275 |
Brugia malayi | hypothetical protein | 0.008 | 0.2177 | 0.215 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.2653 | 0.3925 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.676 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.2177 | 0.3221 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2177 | 0.5 |
Echinococcus granulosus | jun protein | 0.009 | 0.2653 | 0.3925 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.676 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2177 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1787 | 0.1755 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.2653 | 0.2631 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0053 | 0.5 |
Onchocerca volvulus | 0.0162 | 0.5879 | 0.5857 | |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1103 | 0.1566 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.8618 | 0.8667 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0253 | 0.9936 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0253 | 0.9936 | 1 |
Echinococcus granulosus | geminin | 0.0182 | 0.676 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1898 | 0.275 |
Echinococcus multilocularis | jun protein | 0.009 | 0.2653 | 0.3877 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.2653 | 0.3877 |
Echinococcus multilocularis | geminin | 0.0182 | 0.676 | 1 |
Brugia malayi | hypothetical protein | 0.0162 | 0.5879 | 0.5895 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2543 | 0.2519 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5879 | 0.5895 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2177 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.8618 | 0.8667 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0053 | 0.0078 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.2177 | 0.3168 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.2177 | 0.3168 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2177 | 0.3168 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0053 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2177 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0253 | 0.9936 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 1 | 0.5 |
Onchocerca volvulus | 0.0071 | 0.1787 | 0.1743 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.