Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0837 | 0.5 |
Echinococcus multilocularis | Aminotransferase class III | 0.0021 | 0.0114 | 0.5 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0149 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0837 | 1 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0021 | 0.0114 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.9656 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0021 | 0.0114 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0837 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0837 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0021 | 0.0114 | 0.5 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0021 | 0.0114 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0837 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0837 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0149 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0837 | 0.5 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0149 | 1 | 1 |
Echinococcus granulosus | ornithine aminotransferase | 0.0021 | 0.0114 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0837 | 0.0866 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0149 | 1 | 1 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0021 | 0.0114 | 0.0119 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0021 | 0.0114 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.9656 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0837 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0021 | 0.0114 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.9656 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0149 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.7016 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.