Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0139 | 0.935 | 0.935 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.935 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0773 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.301 | 0.301 |
Loa Loa (eye worm) | TAR-binding protein | 0.0139 | 0.935 | 0.935 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.301 | 0.301 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0773 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.301 | 0.3219 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.8406 | 0.8406 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.301 | 0.3219 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.8406 | 0.8406 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0139 | 0.935 | 0.935 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.935 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0773 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.301 | 0.3219 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0773 | 0.0773 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.935 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.301 | 0.3219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.935 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0139 | 0.935 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.301 | 0.3219 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0773 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0773 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0139 | 0.935 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.301 | 0.3219 |
Brugia malayi | TAR-binding protein | 0.0139 | 0.935 | 0.935 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0773 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0773 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0139 | 0.935 | 0.935 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.8406 | 0.8406 |
Brugia malayi | RNA binding protein | 0.0139 | 0.935 | 0.935 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0088 | 0.0088 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0773 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.301 | 0.3219 |
Onchocerca volvulus | 0.0148 | 1 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.935 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.