Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0679 | 0.0679 |
Brugia malayi | TAR-binding protein | 0.0194 | 0.4767 | 0.4767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.4767 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0379 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.4767 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0253 | 0.0253 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0793 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0793 | 0.0793 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0194 | 0.4767 | 0.4767 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0233 | 0.0488 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0194 | 0.4767 | 0.4767 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0054 | 0.0793 | 0.5 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0793 | 0.0793 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0793 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0054 | 0.0793 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0233 | 0.0233 |
Echinococcus granulosus | tar DNA binding protein | 0.0194 | 0.4767 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0679 | 0.0679 |
Brugia malayi | RNA binding protein | 0.0194 | 0.4767 | 0.4767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.4767 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0194 | 0.4767 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.0793 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0679 | 0.0679 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.0793 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0194 | 0.4767 | 0.4767 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.0793 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0379 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.4767 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0194 | 0.4767 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0233 | 0.0233 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.0793 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0194 | 0.4767 | 0.4767 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.