Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 2 | 0.0252 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0252 | 1 | 0.5 |
Onchocerca volvulus | 0.0252 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.0252 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0252 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0252 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0252 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0252 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0252 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0158 | 0.4604 | 0.4604 |
Echinococcus granulosus | hexokinase | 0.0252 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0123 | 0.0123 |
Brugia malayi | Hexokinase family protein | 0.0252 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0252 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0252 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hexokinase | 0.0252 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0252 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0252 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0252 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.5396 | 0.5396 |
Trypanosoma cruzi | hexokinase, putative | 0.0252 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0252 | 1 | 0.5 |
Onchocerca volvulus | 0.0252 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0158 | 0.4604 | 0.4604 |
Echinococcus multilocularis | hexokinase | 0.0252 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0252 | 1 | 0.5 |
Onchocerca volvulus | 0.0252 | 1 | 1 | |
Schistosoma mansoni | hexokinase | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0252 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.008 | 0.0123 | 0.0123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.