Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase | 0.0631 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0631 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0631 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0631 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0631 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0201 | 0.0123 | 0.0123 |
Plasmodium vivax | hexokinase, putative | 0.0631 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0396 | 0.4604 | 0.4604 |
Echinococcus multilocularis | hexokinase | 0.0631 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0631 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0631 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0631 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0631 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0123 | 0.0123 |
Echinococcus multilocularis | hexokinase | 0.0631 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0631 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0631 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0631 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0631 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0631 | 1 | 1 |
Onchocerca volvulus | 0.0631 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.5396 | 0.5396 |
Trypanosoma cruzi | hexokinase, putative | 0.0631 | 1 | 0.5 |
Onchocerca volvulus | 0.0631 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0396 | 0.4604 | 0.4604 |
Loa Loa (eye worm) | hexokinase | 0.0631 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0631 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0631 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0631 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0123 | 0.0123 |
Onchocerca volvulus | 0.0631 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0631 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0631 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0631 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0631 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.