Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase type 2 | 0.0164 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0164 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0123 | 0.0123 |
Trypanosoma brucei | hexokinase | 0.0164 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0164 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0164 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0164 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0164 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0164 | 1 | 0.5 |
Onchocerca volvulus | 0.0164 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.0164 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0103 | 0.4604 | 0.4604 |
Trypanosoma brucei | hexokinase, putative | 0.0164 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0164 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0164 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0164 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0164 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0164 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0164 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0123 | 0.0123 |
Leishmania major | hexokinase, putative | 0.0164 | 1 | 0.5 |
Onchocerca volvulus | 0.0164 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0164 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0164 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0103 | 0.4604 | 0.4604 |
Loa Loa (eye worm) | hexokinase | 0.0164 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0164 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0164 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.5396 | 0.5396 |
Brugia malayi | hexokinase type II | 0.0052 | 0.0123 | 0.0123 |
Toxoplasma gondii | hexokinase | 0.0164 | 1 | 0.5 |
Onchocerca volvulus | 0.0164 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase type II | 0.0164 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0164 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1585 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.