Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.0649 | 0.5047 | 0.5089 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0707 | 0.5862 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.3081 | 0.2358 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0649 | 0.5047 | 0.7321 |
Echinococcus granulosus | integrin beta 2 | 0.0524 | 0.328 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0524 | 0.328 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.2818 | 0.2068 |
Schistosoma mansoni | integrin beta subunit | 0.0416 | 0.1766 | 0.1781 |
Echinococcus multilocularis | integrin alpha 3 | 0.0497 | 0.2911 | 0.8877 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0994 | 0.9916 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0497 | 0.2911 | 0.8877 |
Loa Loa (eye worm) | integrin beta-2 | 0.0707 | 0.5862 | 0.543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 53 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
LD50 (ADMET) | = 53 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
No. of positive cases (functional) | = 3 | Incidence of arrhythmias in rats after a intravenal administration at 4mg/kg, expressed as no. of positive cases out of no. of tested cases (10) | ChEMBL. | 3806567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.