Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | LCCL domain-containing protein | 0.0099 | 0 | 0.5 |
Echinococcus multilocularis | macrophage expressed protein | 0.0499 | 0.8079 | 0.8079 |
Schistosoma mansoni | lipoxygenase | 0.0416 | 0.6387 | 0.6387 |
Schistosoma mansoni | lipoxygenase | 0.0595 | 1 | 1 |
Brugia malayi | Doublecortin family protein | 0.0099 | 0 | 0.5 |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0595 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0099 | 0 | 0.5 |
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0499 | 0.8079 | 0.8079 |
Brugia malayi | hypothetical protein | 0.0099 | 0 | 0.5 |
Echinococcus granulosus | macrophage expressed protein | 0.0499 | 0.8079 | 0.8079 |
Brugia malayi | hypothetical protein | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.0099 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.