Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0249 | 0.3907 | 0.3907 |
Trypanosoma brucei | N-myristoyltransferase | 0.0348 | 0.5699 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0034 | 0 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0348 | 0.5699 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0348 | 0.5699 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0348 | 0.5699 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0348 | 0.5699 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus multilocularis | chromobox protein 2 | 0.0584 | 1 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0249 | 0.3907 | 0.6856 |
Schistosoma mansoni | N-myristoyltransferase | 0.0348 | 0.5699 | 0.5699 |
Giardia lamblia | CDC72 | 0.0348 | 0.5699 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0348 | 0.5699 | 1 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0348 | 0.5699 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0249 | 0.3907 | 0.3907 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0249 | 0.3907 | 0.3907 |
Brugia malayi | N-myristoyltransferase 2 | 0.0348 | 0.5699 | 1 |
Schistosoma mansoni | chromobox protein | 0.0584 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0034 | 0 | 0.5 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0228 | 0.3532 | 0.6197 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0348 | 0.5699 | 0.5699 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0348 | 0.5699 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0249 | 0.3907 | 0.6856 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0348 | 0.5699 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0348 | 0.5699 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0348 | 0.5699 | 0.5699 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6702 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.