Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0032 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0032 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.6591 | 0.6591 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0032 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0032 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0025 | 0.6591 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0.6591 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0032 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0025 | 0.6591 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.6591 | 0.6591 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0032 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0025 | 0.6591 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0025 | 0.6591 | 0.6591 |
Leishmania major | cytochrome p450-like protein | 0.0025 | 0.6591 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0032 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0032 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 1 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.6591 | 0.6591 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.6591 | 0.6591 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0032 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3106 | 0.3106 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.