Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Heat shock protein 83, putative | 0.1035 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0913 | 0.7732 | 0.7571 |
Trichomonas vaginalis | heat shock protein, putative | 0.0683 | 0.345 | 0.345 |
Schistosoma mansoni | heat shock protein | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0885 | 0.7211 | 0.1916 |
Trichomonas vaginalis | heat shock protein, putative | 0.0885 | 0.7211 | 0.7211 |
Plasmodium falciparum | heat shock protein 90 | 0.1035 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.1035 | 1 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0948 | 0.8393 | 0.5343 |
Trypanosoma brucei | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.1035 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0885 | 0.7211 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.1035 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0683 | 0.345 | 0.2987 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein, putative | 0.0948 | 0.8393 | 0.4239 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1035 | 1 | 1 |
Brugia malayi | heat shock protein 90 | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0885 | 0.7211 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0885 | 0.7211 | 0.7211 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0885 | 0.7211 | 0.5 |
Trypanosoma cruzi | heat shock protein, putative | 0.0948 | 0.8393 | 0.8264 |
Schistosoma mansoni | endoplasmin | 0.1035 | 1 | 1 |
Echinococcus multilocularis | heat shock protein | 0.1035 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0948 | 0.8393 | 0.5 |
Trichomonas vaginalis | endoplasmin, putative | 0.0683 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.0885 | 0.7211 | 0.1916 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0948 | 0.8393 | 0.5343 |
Treponema pallidum | heat shock protein 90 | 0.0885 | 0.7211 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.1035 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.1035 | 1 | 1 |
Plasmodium vivax | heat shock protein 90, putative | 0.0948 | 0.8393 | 0.8279 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.1035 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0849 | 0.655 | 0.6272 |
Giardia lamblia | Grp94/Hsp90 | 0.0885 | 0.7211 | 0.1916 |
Schistosoma mansoni | heat shock protein | 0.1035 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0849 | 0.655 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0948 | 0.8393 | 0.8279 |
Loa Loa (eye worm) | heat shock protein 90 | 0.1035 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.1035 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.1035 | 1 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0885 | 0.7211 | 0.5 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1035 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.1035 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.1035 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.1035 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0849 | 0.655 | 0.6272 |
Leishmania major | heat shock protein 83-1 | 0.1035 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.