Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine protein kinase ATM | 0.0027 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.5386 | 0.5386 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.002 | 0.541 | 1 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.002 | 0.541 | 0.541 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.002 | 0.5386 | 0.5386 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.5386 | 0.4987 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.002 | 0.5386 | 0.5386 |
Toxoplasma gondii | FATC domain-containing protein | 0.0027 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.002 | 0.5386 | 0.5386 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.5386 | 0.7065 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.002 | 0.5386 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.002 | 0.5386 | 0.4987 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 1 | 1 |
Echinococcus granulosus | serine protein kinase ATM | 0.0027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0796 | 0.1044 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Giardia lamblia | GTOR | 0.002 | 0.5386 | 0.5 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.002 | 0.5386 | 0.7065 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.002 | 0.5386 | 0.4987 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0796 | 0.0796 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.002 | 0.5386 | 0.5386 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.002 | 0.5386 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.002 | 0.5386 | 0.5386 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0027 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.002 | 0.5386 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0023 | 0.7623 | 0.7623 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0012 | 0.0796 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.7623 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.002 | 0.5386 | 0.5386 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 7.3 nM | Antimalarial activity against asexual blood stage form of Plasmodium falciparum Dd2 infected in human erythrocytes after 72 hrs by DAPI staining | ChEMBL. | 22328964 |
IC50 (binding) | 69.527 uM | PubChem BioAssay. Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.