Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0255 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Onchocerca volvulus | 0.0255 | 1 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0255 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 1 | 1 |
Onchocerca volvulus | 0.0255 | 1 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0255 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0255 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1401 | 0.1401 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1401 | 0.1401 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0255 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.0255 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0255 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0255 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1401 | 0.1401 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0255 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0255 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0255 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1401 | 0.1401 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1401 | 0.1401 |
Schistosoma mansoni | peroxidasin | 0.0255 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0255 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1853 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.