Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0244 | 0.9844 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7073 | 0.6567 |
Echinococcus granulosus | geminin | 0.0205 | 0.7073 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0244 | 0.9844 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.013 | 0.1773 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.013 | 0.1773 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0138 | 0.2344 | 0.2344 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7073 | 0.6567 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.013 | 0.1773 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.013 | 0.1773 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.013 | 0.1773 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7073 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.013 | 0.1773 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0244 | 0.9844 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0244 | 0.9844 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.013 | 0.1773 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0244 | 0.9844 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1158 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.2512 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.