Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | mitochondrial ATP synthase F1, epsilon subunit, putative | 0.0057 | 0.9303 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0044 | 0.6052 | 1 |
Brugia malayi | ATP synthase delta chain, mitochondrial precursor, putative | 0.0024 | 0.1063 | 0.1063 |
Leishmania major | ATP synthase, epsilon chain, putative | 0.0024 | 0.1063 | 0.2587 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.528 | 0.528 |
Echinococcus granulosus | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0057 | 0.9303 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit epsilon | 0.0024 | 0.1063 | 0.1757 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0044 | 0.6052 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit epsilon | 0.0024 | 0.1063 | 0.1757 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0044 | 0.6052 | 1 |
Echinococcus multilocularis | ATP synthase subunit delta, mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE EPSILON CHAIN ATPC | 0.0024 | 0.1063 | 0.1757 |
Toxoplasma gondii | ATP synthase, putative | 0.0024 | 0.1063 | 0.1143 |
Loa Loa (eye worm) | ATP synthase subunit epsilon | 0.0057 | 0.9303 | 0.9303 |
Schistosoma mansoni | ATP synthase delta chain mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0044 | 0.6052 | 0.6505 |
Onchocerca volvulus | ATP synthase subunit delta, mitochondrial homolog | 0.0024 | 0.1063 | 0.1757 |
Trypanosoma brucei | mitochondrial ATP synthase delta chain | 0.0024 | 0.1063 | 0.2587 |
Echinococcus granulosus | 5'partial|ATP synthase subunit delta mitochondrial | 0.0024 | 0.1063 | 0.1143 |
Plasmodium vivax | ATP synthase epsilon chain, mitochondrial , putative | 0.0057 | 0.9303 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0044 | 0.6052 | 1 |
Echinococcus multilocularis | mitochondrial F1F0 ATP synthase subunit epsilon | 0.0057 | 0.9303 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0044 | 0.6052 | 1 |
Leishmania major | ATPase alpha subunit | 0.0036 | 0.4109 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.528 | 0.5675 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0044 | 0.6052 | 0.6505 |
Plasmodium falciparum | ATP synthase subunit delta, mitochondrial, putative | 0.0024 | 0.1063 | 0.1143 |
Mycobacterium tuberculosis | Probable ATP synthase epsilon chain AtpC | 0.0024 | 0.1063 | 0.1757 |
Trypanosoma cruzi | ATP synthase, epsilon chain, putative | 0.0024 | 0.1063 | 1 |
Brugia malayi | ATP synthase epsilon chain, mitochondrial | 0.0057 | 0.9303 | 0.9303 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.528 | 0.528 |
Plasmodium vivax | hypothetical protein, conserved | 0.0024 | 0.1063 | 0.1143 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0044 | 0.6052 | 1 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0036 | 0.4109 | 1 |
Toxoplasma gondii | atp synthase F1, epsilon subunit, putative | 0.0057 | 0.9303 | 1 |
Leishmania major | ATPase alpha subunit | 0.0036 | 0.4109 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0044 | 0.6052 | 0.6505 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0044 | 0.6052 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0044 | 0.6052 | 0.6052 |
Loa Loa (eye worm) | ATP synthase subunit delta | 0.0024 | 0.1063 | 0.1063 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0036 | 0.4109 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.9303 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.