Detailed view for PF3D7_0715500

Basic information

TDR Targets ID: 580
Plasmodium falciparum, mitochondrial ATP synthase F1, epsilon subunit, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.807 | Length (AA): 71 | MW (Da): 8496 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04627   Mitochondrial ATP synthase epsilon chain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046933   hydrogen ion transporting ATP synthase activity, rotational mechanism  
GO:0005753   mitochondrial proton-transporting ATP synthase complex  
GO:0000275   mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 44 2v7q (I) 3 46 30.00 0 0.08 0.828418 0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late schizont, late trophozoite, Oocyst, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, sporozoite, late ring, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_129865)

Species Accession Gene Product
Arabidopsis thaliana AT1G51650   ATP synthase subunit epsilon
Babesia bovis BBOV_IV007710   conserved hypothetical protein
Brugia malayi Bm1_00120   ATP synthase epsilon chain, mitochondrial
Caenorhabditis elegans CELE_F32D1.2   Protein HPO-18
Dictyostelium discoideum DDB_G0276241   ATP synthase epsilon chain, mitochondrial
Drosophila melanogaster Dmel_CG31477   CG31477 gene product from transcript CG31477-RB
Drosophila melanogaster Dmel_CG9032   stunted
Echinococcus granulosus EgrG_001153000   mitochondrial F1F0 ATP synthase subunit epsilon
Echinococcus multilocularis EmuJ_001153000   mitochondrial F1F0 ATP synthase subunit epsilon
Homo sapiens 514   ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
Loa Loa (eye worm) LOAG_06473   ATP synthase subunit epsilon
Mus musculus ENSMUSG00000016252   ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
Neospora caninum NCLIV_057710   ATP synthase epsilon chain, putative
Oryza sativa 4345078   Os08g0250200
Plasmodium berghei PBANKA_1421800   mitochondrial ATP synthase F1, epsilon subunit, putative
Plasmodium falciparum PF3D7_0715500   mitochondrial ATP synthase F1, epsilon subunit, putative
Plasmodium knowlesi PKNH_1424500   mitochondrial ATP synthase F1, epsilon subunit, putative
Plasmodium vivax PVX_122980   ATP synthase epsilon chain, mitochondrial , putative
Plasmodium yoelii PY02879   hypothetical protein
Saccharomyces cerevisiae YPL271W   F1F0 ATP synthase subunit epsilon
Schistosoma japonicum Sjp_0036020   IPR006721,ATPase, F1 complex, epsilon subunit, mitochondrial,domain-containing
Schistosoma mansoni Smp_064330   hypothetical protein
Toxoplasma gondii TGME49_314820   atp synthase F1, epsilon subunit, putative
Theileria parva TP03_0278   mitochondrial ATP synthase F1, epsilon subunit, putative

Essentiality

PF3D7_0715500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F32D1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32D1.2 Caenorhabditis elegans larval arrest wormbase
CELE_F32D1.2 Caenorhabditis elegans larval lethal wormbase
CELE_F32D1.2 Caenorhabditis elegans slow growth wormbase
CELE_F32D1.2 Caenorhabditis elegans sterile wormbase
TGME49_314820 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus Mitochondrial complex V; ATP synthase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0435 1 1
0.0276 1 1
0.0057 0.9303 1
0.0431 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

11 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0715500 (Plasmodium falciparum), mitochondrial ATP synthase F1, epsilon subunit, putative
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