Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA topoisomerase II, putative | 0.01 | 0.1747 | 0.1747 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.01 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0977 | 0.5592 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.01 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0248 | 0.5455 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.01 | 0.1747 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.4372 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.01 | 0.1747 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0148 | 0.2938 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.01 | 0.1747 | 0.3996 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.01 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0281 | 0.6292 | 0.6292 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0977 | 0.5592 |
Giardia lamblia | DNA topoisomerase II | 0.0087 | 0.1409 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0248 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0248 | 0.5455 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0429 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0429 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0429 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4372 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.01 | 0.1747 | 0.3202 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4372 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4372 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0248 | 0.5455 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.01 | 0.1747 | 0.3996 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0248 | 0.5455 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.01 | 0.1747 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0429 | 1 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.007 | 0.0977 | 0.1791 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0429 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0977 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.007 | 0.0977 | 0.1791 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.01 | 0.1747 | 0.3996 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.01 | 0.1747 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.01 | 0.1747 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.01 | 0.1747 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.01 | 0.1747 | 0.1747 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0429 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.007 | 0.0977 | 0.1791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.1735 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.