Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.043 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.043 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0047 | 0.043 | 0.043 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0.043 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0045 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0.043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0.043 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0047 | 0.043 | 0.043 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 47.7548 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.