Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.069 | 0.2276 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0527 | 0.069 | 0.2276 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Schistosoma mansoni | patched 1 | 0.0527 | 0.069 | 0.2276 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.128 | 0.3031 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0527 | 0.069 | 0.2276 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.128 | 0.3031 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0527 | 0.069 | 0.2276 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.128 | 0.3031 | 0.5 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.128 | 0.3031 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.128 | 0.3031 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.128 | 0.3031 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.128 | 0.3031 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.06 | 0.0919 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.128 | 0.3031 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.128 | 0.3031 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.128 | 0.3031 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.06 | 0.0919 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 100 % | Inhibition of rat glial cell gap junction at the concentration of 50 microM | ChEMBL. | 10328303 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.