Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.3188 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0278 | 0.7484 | 0.7484 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.2303 | 0.2303 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0278 | 0.7484 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3188 | 0.3697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3188 | 0.3697 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.3188 | 0.3188 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.3188 | 0.3188 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0151 | 0.3711 | 0.3711 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.3188 | 0.3188 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0668 | 0.0668 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0278 | 0.7484 | 0.7484 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0363 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0151 | 0.3711 | 0.3711 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3188 | 0.3697 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.3711 | 0.3711 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2303 | 0.2303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3188 | 0.3697 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.3188 | 0.3188 |
Trichomonas vaginalis | glutaminase, putative | 0.0278 | 0.7484 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2303 | 0.2398 |
Loa Loa (eye worm) | glutaminase | 0.0278 | 0.7484 | 0.7484 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.3188 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0668 | 0.0668 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0151 | 0.3711 | 0.3711 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0668 | 0.0668 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.3188 | 0.3188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.3188 | 0.3697 |
Brugia malayi | RNA binding protein | 0.0133 | 0.3188 | 0.3188 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0668 | 0.0668 |
Schistosoma mansoni | glutaminase | 0.0278 | 0.7484 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0363 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (binding) | = 9.56 | Binding affinity analysed for 5-HT 2B receptor in rat stomach fundus | ChEMBL. | 8709108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.