Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0417 | 0.0437 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1254 | 0.4261 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2944 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0417 | 0.0437 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2944 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.2111 | 0.7171 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.023 | 0.0241 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.2944 | 0.3085 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0777 | 0.0814 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0417 | 0.0437 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0181 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0181 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.023 | 0.0782 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0777 | 0.0814 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0417 | 0.1417 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.2944 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.003 | 0 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0074 | 0.2944 | 0.6526 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.9541 | 1 |
Echinococcus granulosus | geminin | 0.0174 | 0.9541 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.4511 | 0.4728 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.4511 | 0.4728 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0417 | 0.0925 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1254 | 0.278 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.3176 | 0.3329 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0181 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0181 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0181 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0181 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0174 | 0.9541 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.0869 | 0.0911 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.0869 | 0.0911 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0181 | 1 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0074 | 0.2944 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1254 | 0.4261 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0074 | 0.2944 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0074 | 0.2944 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.4511 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.023 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1416 | 0.4812 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.9541 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0074 | 0.2944 | 0.3085 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0417 | 0.0437 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0074 | 0.2944 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1254 | 0.278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.