Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0055 | 0.3953 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3824 | 0.9673 |
Onchocerca volvulus | 0.0053 | 0.3824 | 0.7864 | |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0129 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3348 | 0.8468 |
Schistosoma mansoni | protein kinase C mu | 0.0053 | 0.3839 | 1 |
Brugia malayi | C1-like domain containing protein | 0.0053 | 0.3839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0115 | 0.029 |
Brugia malayi | Pleckstrin Homology Domain | 0.0007 | 0.0115 | 0.0299 |
Schistosoma mansoni | vav2 | 0.0007 | 0.0115 | 0.0299 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0053 | 0.3839 | 0.971 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0007 | 0.0115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3953 | 1 |
Echinococcus granulosus | myotubularin protein 13 | 0.0007 | 0.0115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3348 | 0.8468 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0053 | 0.3839 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0047 | 0.3362 | 0.8504 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0129 | 1 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0129 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.