Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 5 | Starlite/ChEMBL | No references |
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | sphingosine-1-phosphate receptor 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0075 | 0.3935 | 0.3935 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0176 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0466 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0075 | 0.3935 | 0.3935 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0176 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.1146 | 0.0713 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0176 | 1 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0176 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0176 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0017 | 0.0466 | 0.5 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0176 | 1 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0176 | 1 | 0.5 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0466 | 0.0466 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0466 | 0.0466 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0466 | 0.0466 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0017 | 0.0466 | 0.5 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.1146 | 0.1146 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0017 | 0.0466 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0886 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400] | ChEMBL. | No reference |
EC50 (functional) | = 0.1127 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 1 (S1P1) counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463107, AID463225, AID504400] | ChEMBL. | No reference |
EC50 (functional) | = 0.339 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 5 (S1P5) counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463107, AID463225, AID504400] | ChEMBL. | No reference |
EC50 (functional) | > 50 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 2 (S1P2) counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463107, AID463225, AID504400] | ChEMBL. | No reference |
EC50 (functional) | > 50 uM | PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 3 (S1P3) counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463107, AID463225, AID504400] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.