Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6896 | 0.8181 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0074 | 0.3307 | 0.3923 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0174 | 0.843 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0174 | 0.843 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0174 | 0.843 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6896 | 0.8181 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0174 | 0.843 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6896 | 0.8181 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0174 | 0.843 | 0.5 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0174 | 0.843 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0074 | 0.3307 | 0.3923 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0174 | 0.843 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0174 | 0.843 | 0.5 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0174 | 0.843 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0174 | 0.843 | 0.5 |
Brugia malayi | Bm-MIF-1, identical | 0.0174 | 0.843 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.