Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 2 | 872 aa | 822 aa | 21.2 % |
Onchocerca volvulus | Metabotropic glutamate receptor 2 | 872 aa | 774 aa | 20.4 % | |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 2 | 872 aa | 884 aa | 35.3 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 2 | 872 aa | 892 aa | 26.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 2 | 872 aa | 883 aa | 43.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0122 | 0.7838 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.006 | 0.3042 | 0.3881 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0048 | 0.2162 | 0.2162 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0111 | 0.6958 | 0.8878 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0139 | 0.912 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.015 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.006 | 0.3042 | 0.3335 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0031 | 0.088 | 0.088 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0102 | 0.6319 | 0.6319 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0031 | 0.088 | 0.1122 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0102 | 0.6319 | 0.6319 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.088 | 0.088 |
Loa Loa (eye worm) | glutamate receptor | 0.0122 | 0.7838 | 0.7838 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0031 | 0.088 | 0.088 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0102 | 0.6319 | 0.6929 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 818 nM | Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced intracellular calcium release by FLIPR assay | ChEMBL. | 21366332 |
Ki (binding) | Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation counting | ChEMBL. | 21366332 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.