Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.1881 | 0.8889 | 1 |
Brugia malayi | hypothetical protein | 0.0895 | 0.4216 | 0.4539 |
Onchocerca volvulus | 0.1881 | 0.8889 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0895 | 0.4216 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0348 | 0.1623 | 0.1336 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0097 | 0.0435 | 0.0269 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2116 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1881 | 0.8889 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2116 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1881 | 0.8889 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2116 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0098 | 0.0438 | 0.0125 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0348 | 0.1623 | 0.1526 |
Loa Loa (eye worm) | IRE protein kinase | 0.0098 | 0.0438 | 0.0125 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0441 | 0.2066 | 0.2027 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0438 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2116 | 1 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0075 | 0.0331 | 0.0219 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0441 | 0.2066 | 0.2027 |
Schistosoma mansoni | dihydrofolate reductase | 0.0441 | 0.2066 | 0.2027 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0441 | 0.2066 | 1 |
Giardia lamblia | CDC8 | 0.0075 | 0.0331 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2116 | 1 | 1 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0098 | 0.0438 | 0.0125 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.0331 | 0.0219 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0075 | 0.0331 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0441 | 0.2066 | 0.2027 |
Echinococcus multilocularis | thymidylate synthase | 0.1881 | 0.8889 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0441 | 0.2066 | 0.2027 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0438 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0075 | 0.0331 | 0.5 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.0331 | 0.0219 |
Mycobacterium ulcerans | thymidylate synthase | 0.1881 | 0.8889 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0441 | 0.2066 | 0.2027 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0895 | 0.4216 | 0.4539 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0441 | 0.2066 | 0.2027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0097 | 0.0435 | 0.0269 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0348 | 0.1623 | 0.1526 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0098 | 0.0438 | 0.0125 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1881 | 0.8889 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.0438 | 0.0125 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0895 | 0.4216 | 0.4148 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0348 | 0.1623 | 0.1526 |
Brugia malayi | thymidylate synthase | 0.1881 | 0.8889 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0441 | 0.2066 | 0.2027 |
Brugia malayi | Dihydrofolate reductase | 0.0441 | 0.2066 | 0.2027 |
Loa Loa (eye worm) | thymidylate synthase | 0.1881 | 0.8889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.92 uM | Antiproliferative activity against human MCF7 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
IC50 (functional) | = 20.3 uM | Antiproliferative activity against mouse B16F10 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
IC50 (binding) | = 38.32 uM | Inhibition of recombinant His6-tagged EGFR expressed in baculovirus infected insect Sf9 cells using ATP as substrate and cofactor MgCl2 after 2 hrs by DELFIA/Time-resolved fluorometric analysis | ChEMBL. | 22119130 |
IC50 (functional) | = 47 uM | Antiproliferative activity against human A549 cells overexpressing EGFR gene after 48 hrs by MTT assay | ChEMBL. | 22119130 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22119130 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.