Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.6798 | 0.6654 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3693 | 0.3408 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0171 | 0.6798 | 0.6456 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 0.6879 | 0.0252 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0966 | 0.0966 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0228 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0171 | 0.6798 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.3099 | 0.2787 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0172 | 0.6879 | 0.0252 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0171 | 0.6798 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.6798 | 0.6798 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0228 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0228 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0228 | 1 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0171 | 0.6798 | 0.6654 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.3632 | 0.3344 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.6798 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.3099 | 0.2361 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.6798 | 0.6798 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3693 | 0.3408 |
Plasmodium vivax | RNA helicase-1, putative | 0.0171 | 0.6798 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0228 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.0966 | 0.0557 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0171 | 0.6798 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0171 | 0.6798 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0171 | 0.6798 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.6798 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.6798 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0171 | 0.6798 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0228 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.3099 | 0.2361 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.0433 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0058 | 0.0433 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3693 | 0.3408 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0228 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.6798 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.6798 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0171 | 0.6798 | 0.5 |
Onchocerca volvulus | 0.0228 | 1 | 1 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0171 | 0.6798 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0228 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.3632 | 0.3344 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0171 | 0.6798 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.