Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 4 | 912 aa | 881 aa | 20.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 4 | 912 aa | 874 aa | 39.1 % |
Onchocerca volvulus | Metabotropic glutamate receptor 4 | 912 aa | 841 aa | 21.0 % | |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 4 | 912 aa | 826 aa | 34.7 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 4 | 912 aa | 903 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | 0.2009 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0378 | 0.1682 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0102 | 0.0277 | 0.022 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.015 | 0.0522 | 0.0252 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.2009 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.1682 | 0.1682 |
Loa Loa (eye worm) | glutamate receptor | 0.0122 | 0.0378 | 0.0378 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.2009 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.2009 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0378 | 0.1682 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0378 | 0.1682 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0111 | 0.032 | 0.0262 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0122 | 0.0378 | 0.0321 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.015 | 0.0522 | 0.0252 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0378 | 0.1682 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.074 | 0.074 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.2009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0522 | 0.0522 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0139 | 0.0464 | 0.0407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 61.5 % | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
Activity (binding) | = 105.5 % | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
EC50 (binding) | = 403 nM | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
EC50 (binding) | = 533 nM | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
Inhibition (binding) | Inhibition of human CYP3A4 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP2C9 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP2D6 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP1A2 | ChEMBL. | 21247167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.