Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | triose-phosphate isomerase TPI-I | 0.0091 | 0.7857 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.007 | 0.4982 | 0.4982 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.5371 | 0.5371 |
Mycobacterium leprae | Probable triosephosphate isomerase Tpi (TIM) | 0.0091 | 0.7857 | 1 |
Mycobacterium ulcerans | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.5371 | 0.6836 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 1 | 1 |
Chlamydia trachomatis | triosephosphate isomerase | 0.0091 | 0.7857 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.007 | 0.4982 | 0.6129 |
Loa Loa (eye worm) | triosephosphate isomerase | 0.0091 | 0.7857 | 0.7857 |
Treponema pallidum | triosephosphate isomerase | 0.0091 | 0.7857 | 0.5 |
Plasmodium vivax | triosephosphate isomerase, putative | 0.0091 | 0.7857 | 1 |
Trichomonas vaginalis | triosephosphate isomerase, putative | 0.0091 | 0.7857 | 1 |
Entamoeba histolytica | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Trichomonas vaginalis | triosephosphate isomerase, putative | 0.0091 | 0.7857 | 1 |
Giardia lamblia | Triosephosphate isomerase, cytosolic | 0.0091 | 0.7857 | 1 |
Mycobacterium tuberculosis | Probable triosephosphate isomerase Tpi (TIM) | 0.0091 | 0.7857 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 1 | 1 |
Echinococcus multilocularis | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Trypanosoma cruzi | triosephosphate isomerase, putative | 0.0091 | 0.7857 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.007 | 0.4982 | 0.634 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.007 | 0.4982 | 0.4982 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.007 | 0.4982 | 0.634 |
Plasmodium falciparum | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Toxoplasma gondii | triose-phosphate isomerase TPI-II | 0.0091 | 0.7857 | 1 |
Trypanosoma brucei | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.007 | 0.4982 | 0.6129 |
Schistosoma mansoni | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.007 | 0.4982 | 0.634 |
Leishmania major | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Brugia malayi | triosephosphate isomerase | 0.0091 | 0.7857 | 0.7857 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 1 | 1 |
Echinococcus granulosus | triosephosphate isomerase | 0.0091 | 0.7857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5371 | 0.5371 |
Schistosoma mansoni | triosephosphate isomerase | 0.0037 | 0.0429 | 0.0546 |
Wolbachia endosymbiont of Brugia malayi | triosephosphate isomerase | 0.0091 | 0.7857 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 10 % | Growth inhibition of human MCF7 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 12 % | Growth inhibition of human MCF7 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 16 % | Growth inhibition of human Hep2 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 22 % | Growth inhibition of human IMR32 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 24 % | Growth inhibition of human HeLa cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 27 % | Growth inhibition of human PC3 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 29 % | Growth inhibition of human OVCAR5 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 30 % | Growth inhibition of human Hep2 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 33 % | Growth inhibition of human A549 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 39 % | Growth inhibition of human THP1 cells at 30 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 42 % | Growth inhibition of human OVCAR5 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 48 % | Growth inhibition of human A549 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 50 % | Growth inhibition of human HeLa cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 50 % | Growth inhibition of human PC3 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 52 % | Growth inhibition of human IMR32 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
GI (functional) | = 52 % | Growth inhibition of human THP1 cells at 50 uM after 48 hrs by sulpharhodamine B assay | ChEMBL. | 22245048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.