Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0112 | 0.0933 | 0.0657 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0933 | 0.15 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0168 | 0.2051 | 0.1809 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0191 | 0.249 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0383 | 0.0169 |
Schistosoma mansoni | ryanodine receptor related | 0.0342 | 0.5504 | 1 |
Onchocerca volvulus | 0.0222 | 0.3111 | 0.3431 | |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0277 | 0.421 | 0.4034 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0156 | 0.1813 | 0.2916 |
Brugia malayi | Disintegrin family protein | 0.0168 | 0.2051 | 0.2965 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0105 | 0.0785 | 0.0941 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0191 | 0.249 | 0.3706 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Loa Loa (eye worm) | disintegrin family protein | 0.0123 | 0.114 | 0.1834 |
Loa Loa (eye worm) | matrixin family protein | 0.0347 | 0.5596 | 0.9001 |
Brugia malayi | Matrixin family protein | 0.0156 | 0.1813 | 0.2563 |
Mycobacterium ulcerans | hydrolase | 0.0191 | 0.249 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0277 | 0.421 | 0.4034 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0168 | 0.2051 | 0.1809 |
Brugia malayi | Hemopexin family protein | 0.0222 | 0.3111 | 0.4755 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0342 | 0.5504 | 0.8796 |
Loa Loa (eye worm) | ryanodine receptor | 0.0128 | 0.1246 | 0.2004 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0112 | 0.0933 | 0.0657 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.3111 | 0.5406 |
Loa Loa (eye worm) | ryanodine receptor | 0.0081 | 0.0311 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2999 | 0.4825 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0191 | 0.249 | 0.5 |
Brugia malayi | cation channel family protein | 0.0146 | 0.1613 | 0.2225 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0569 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.249 | 0.4005 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1813 | 0.2916 |
Onchocerca volvulus | Matrilysin homolog | 0.0347 | 0.5596 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0373 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0216 | 0.2999 | 0.2787 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0123 | 0.1157 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0347 | 0.5596 | 1 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0168 | 0.2051 | 0.3371 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0156 | 0.1813 | 0.2914 |
Brugia malayi | Matrixin family protein | 0.0378 | 0.6217 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0123 | 0.1157 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0378 | 0.6217 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0216 | 0.2999 | 0.2787 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0165 | 0.1985 | 0.3245 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.