Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Muscle positioning protein 4 | 0.0053 | 0.0363 | 0.0143 |
Echinococcus multilocularis | enteropeptidase | 0.014 | 0.2661 | 0.7679 |
Echinococcus granulosus | enteropeptidase | 0.014 | 0.2661 | 0.7679 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0407 | 0.9669 | 0.9661 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0166 | 0.3344 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0363 | 0.0143 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0166 | 0.3344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Leishmania major | hypothetical protein, conserved | 0.0166 | 0.3344 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0166 | 0.3344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0363 | 0.0143 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.014 | 0.2661 | 0.7679 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Onchocerca volvulus | 0.0166 | 0.3344 | 0.3301 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0166 | 0.3344 | 0.3301 |
Brugia malayi | Protein kinase domain containing protein | 0.0166 | 0.3344 | 0.3301 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.014 | 0.2661 | 0.2577 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0166 | 0.3344 | 0.5 |
Brugia malayi | Trypsin family protein | 0.014 | 0.2661 | 0.2577 |
Toxoplasma gondii | kringle domain-containing protein | 0.0166 | 0.3344 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.014 | 0.2661 | 0.7679 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Brugia malayi | Trypsin-like protease protein 5 | 0.014 | 0.2661 | 0.2577 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Loa Loa (eye worm) | trypsin family protein | 0.014 | 0.2661 | 0.2577 |
Brugia malayi | Trypsin family protein | 0.014 | 0.2661 | 0.2577 |
Brugia malayi | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.3344 | 0.3301 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0166 | 0.3344 | 1 |
Onchocerca volvulus | 0.0407 | 0.9669 | 1 | |
Onchocerca volvulus | 0.014 | 0.2661 | 0.2577 | |
Brugia malayi | Kringle domain containing protein | 0.0166 | 0.3344 | 0.3301 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.014 | 0.2661 | 0.7679 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0144 | 0.2764 | 0.2595 |
Onchocerca volvulus | 0.014 | 0.2661 | 0.2577 | |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.9669 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.014 | 0.2661 | 0.7679 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Mycobacterium ulcerans | hypothetical protein | 0.014 | 0.2661 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2661 | 0.2577 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Onchocerca volvulus | 0.014 | 0.2661 | 0.2577 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.014 | 0.2661 | 0.7679 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.2661 | 0.2489 |
Onchocerca volvulus | 0.014 | 0.2661 | 0.2577 | |
Brugia malayi | Trypsin family protein | 0.014 | 0.2661 | 0.2577 |
Onchocerca volvulus | 0.014 | 0.2661 | 0.2577 | |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.9669 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.014 | 0.2661 | 0.7679 |
Onchocerca volvulus | 0.0267 | 0.5986 | 0.6099 | |
Echinococcus granulosus | Mastin | 0.014 | 0.2661 | 0.7679 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.014 | 0.2661 | 0.7679 |
Echinococcus multilocularis | Mastin | 0.014 | 0.2661 | 0.7679 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.014 | 0.2661 | 0.2489 |
Brugia malayi | Trypsin family protein | 0.0407 | 0.9669 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.3344 | 0.3189 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.014 | 0.2661 | 0.7679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.