Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0459 | 0.6281 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0714 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0014 | 0.0014 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0083 | 0.08 | 0.08 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0787 | 0.1945 |
Onchocerca volvulus | 0.0301 | 0.3987 | 0.5 | |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.4068 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.4068 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3987 | 0.9799 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0014 | 0.0036 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0014 | 0.0036 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0014 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.4068 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.3987 | 1 |
Leishmania major | squalene monooxygenase-like protein | 0.0407 | 0.5529 | 0.5691 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0014 | 0.0036 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.08 | 0.1966 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0014 | 0.0014 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0014 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0014 | 0.5 |
Leishmania major | lanosterol synthase, putative | 0.0695 | 0.9715 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0714 | 1 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.4068 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.