Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) | 0.0218 | 0 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative | 0.138 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Nek1 | 0.1344 | 0.9698 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.138 | 1 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK16, putative | 0.138 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Nek1 | 0.1344 | 0.9698 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.138 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.138 | 1 | 1 |
Onchocerca volvulus | 0.0461 | 0.209 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0461 | 0.209 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.138 | 1 | 1 |
Plasmodium falciparum | NIMA related kinase 2 | 0.138 | 1 | 0.5 |
Plasmodium vivax | serine/threonine-protein kinase Nek1, putative | 0.138 | 1 | 0.5 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.138 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.138 | 1 | 1 |
Leishmania major | protein kinase, putative,serine/threonine-protein kinase Nek1, putative | 0.138 | 1 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpB | 0.0218 | 0 | 0.5 |
Plasmodium falciparum | NIMA related kinase 4 | 0.138 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.138 | 1 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.138 | 1 | 1 |
Onchocerca volvulus | 0.0461 | 0.209 | 0.5 | |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK16, putative | 0.138 | 1 | 1 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK11, putative | 0.138 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.138 | 1 | 1 |
Toxoplasma gondii | NEK kinase | 0.138 | 1 | 0.5 |
Plasmodium vivax | serine/threonine-protein kinase NEK4, putative | 0.138 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.138 | 1 | 0.5 |
Toxoplasma gondii | NEK kinase | 0.138 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.138 | 1 | 1 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK11, putative | 0.138 | 1 | 0.5 |
Trypanosoma brucei | NIMA-related protein kinase | 0.138 | 1 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0461 | 0.209 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Protection against Sp-GB-Am-induced toxicity in ip dosed Swiss-Webster mouse assessed as animal survival administered for 5 mins after Sp-GB-Am challenge measured after 24 hrs | ChEMBL. | 22206546 | |
Activity (functional) | Protection against Sp-GB-Am-induced toxicity in Swiss-Webster mouse assessed as animal survival at 36.2 umol/mg, ip administered for 5 mins after Sp-GB-Am challenge measured after 24 hrs | ChEMBL. | 22206546 | |
Activity (functional) | Protection against Sp-GB-Am-induced toxicity in Swiss-Webster mouse assessed as animal survival at 146 umol/mg, ip administered for 5 mins after Sp-GB-Am challenge measured after 24 hrs | ChEMBL. | 22206546 | |
IC50 (binding) | = 157 uM | Inhibition of human recombinant AChE using acetylthiocholine as substrate after 1 hr by Ellman method | ChEMBL. | 22206546 |
IC50 (binding) | > 200 uM | Inhibition of human recombinant BChE using butyrylthiocholine as substrate after 20 mins by Ellman method | ChEMBL. | 22206546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.