Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1178 | 0.4469 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0983 | 0.3602 | 0.3602 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2417 | 1 | 0.5 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0339 | 0.0726 | 0.003 |
Echinococcus granulosus | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Echinococcus multilocularis | alkaline phosphatase | 0.0339 | 0.0726 | 0.003 |
Echinococcus multilocularis | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0641 | 0.2074 | 0.5578 |
Onchocerca volvulus | 0.0202 | 0.0117 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1569 | 0.6216 | 0.4085 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0771 | 0.2653 | 0.7358 |
Mycobacterium ulcerans | carbonic anhydrase | 0.15 | 0.5909 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0983 | 0.3602 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0983 | 0.3602 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2417 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1178 | 0.4469 | 0.4469 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0963 | 0.3514 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0339 | 0.0726 | 0.0726 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0983 | 0.3602 | 0.3602 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1178 | 0.4469 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.15 | 0.5909 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.2417 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.15 | 0.5909 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2417 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2417 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2417 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2417 | 1 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0339 | 0.0726 | 0.003 |
Echinococcus multilocularis | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Echinococcus granulosus | alkaline phosphatase | 0.0339 | 0.0726 | 0.003 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0983 | 0.3602 | 0.3602 |
Echinococcus granulosus | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0339 | 0.0726 | 0.003 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2417 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0339 | 0.0726 | 0.003 |
Echinococcus granulosus | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0983 | 0.3602 | 0.3602 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0339 | 0.0726 | 0.003 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2417 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 0.0698 | 0.0698 |
Schistosoma mansoni | alkaline phosphatase | 0.0339 | 0.0726 | 0.0726 |
Echinococcus multilocularis | carbonic anhydrase | 0.0983 | 0.3602 | 0.3122 |
Schistosoma mansoni | carbonic anhydrase | 0.0983 | 0.3602 | 0.3602 |
Onchocerca volvulus | Putative sulfate transporter | 0.0202 | 0.0117 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2417 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0332 | 0.0698 | 0.0698 |
Echinococcus granulosus | carbonic anhydrase II | 0.2417 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0339 | 0.0726 | 0.003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.38 | Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting | ChEMBL. | 22007643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.