Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0351 | 0.0404 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.005 | 0.0057 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.005 | 0.0057 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0066 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0145 | 0.1248 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0292 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.005 | 0.0035 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0317 | 0.2446 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0066 | 0.0414 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0066 | 0.0414 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0145 | 0.1248 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0015 | 0.0017 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0292 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0066 | 0.0414 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.005 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.005 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.003 | 0.0121 |
Echinococcus multilocularis | kinesin family 1 | 0.112 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0066 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0066 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0015 | 0.0017 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0066 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0015 | 0.0017 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0015 | 0.0017 |
Plasmodium falciparum | kinesin-5 | 0.0145 | 0.1248 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.005 | 0.0035 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0066 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.005 | 0.028 |
Plasmodium vivax | kinesin-5 | 0.0145 | 0.1248 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.005 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0267 | 0.2043 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0066 | 0.0414 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.0351 | 0.0404 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.0317 | 0.0302 |
Giardia lamblia | Kinesin-5 | 0.0145 | 0.1248 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.0317 | 0.0302 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0015 | 0.0017 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0066 | 0.0414 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.0317 | 0.2446 |
Schistosoma mansoni | kinesin eg-5 | 0.0145 | 0.1248 | 0.1435 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0145 | 0.1248 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0145 | 0.1248 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0974 | 0.8693 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | NA 0 mmHg | Antihypertensive activity measured by maximum fall in the mean blood pressure after an oral administration of 1 mg/kg in spontaneously hypertensive rats; NS= Did not lower the blood pressure significantly | ChEMBL. | 2213828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.