Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0138 | 0.6948 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 | |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.6948 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.