Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0025 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | 0.0025 | 0 | 0.5 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0025 | 0 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0025 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0025 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0.9242 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0328 | 0.9071 | 1 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.12 uM | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine after 15 mins by amplex red assay | ChEMBL. | 22005185 |
IC50 (binding) | > 50 uM | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine after 15 mins by amplex red assay | ChEMBL. | 22005185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.